Galerie Mirchandani + Steinruecke's altogether unique position in the field of art has evolved over more than three decades. Usha Mirchandani, who had a career in Advertising at  J. Walter Thompson in New York during the 1970s, experienced the art of her times up close, in some of its most radical and formative moments. Mirchandani returned to Bombay in the early-eighties, and established The Fine Art Resource, the first professional art consultancy in India. She was joined by her daughter, Ranjana, in 1992. 

In 1996, Ranjana moved to Berlin, setting up a gallery that introduced art from the Indian subcontinent in the new German capital through a series of iconic exhibitions – the first being a solo show with Bhupen Khakhar – from which works were acquired by The Reina Sofia Museum in Madrid and the Fonds National d'Art Contemporain in France, among other institutions. In 2003, Usha Mirchandani curated Khakhar's first retrospective in India, at the National Gallery of Modern Art in Mumbai. The gallery also curated the exhibition 'The Artist Lives and Works' at the Haus der Kulturen der Welt in 2005, which showed for the first time in Berlin the work of Shilpa Gupta, N.S. Harsha and Jitish Kallat among other young contemporaries from India.

In 2006, the gallery opened a space in Mumbai. Through the discovery of new talent — and recognising positions of art historical importance —  it developed an impressive portfolio which today includes artists such as C.K. Rajan, Jyothi Basu, Nicola Durvasula, Ratheesh T., Sosa Joseph, Aji V.N., Abir Karmakar and Kulpreet Singh. In 2022, the gallery re-located to a far larger space in Mumbai’s heritage district, Ballard Estate, and in 2024, opened a space in New Delhi’s Defence Colony.